Saturday, January 21, 2012

Jay-Z Makes Post-Baby Appearance At 40/40 Reopening

Ashanti, Spike Lee, Irv Gotti and more of Hov's high-profile friends toast the new dad at renovated NYC club.
By Rob Markman


Jay-Z at the 40/40 Club Reopening
Photo: FilmMagic

NEW YORKJay-Z has a lot to celebrate. A little over a week ago, he and wife Beyoncé welcomed daughter Blue Ivy Carter into the world, and on Wednesday night, big poppa Hov had a bit of business to attend to at the reopening of his 40/40 Club.

The stars came out and walked the red carpet before entering the redesigned sports bar. Jay's buddies Warren Buffet, Spike Lee, Steve Stoute, Kevin Liles and New York Yankees pitcher CC Sabathia all attended.

"Hov always has big parties, so I'm definitely looking forward to going inside and mingling and jingling," Ashanti said.

"We here at the reopening of the 40/40; we about to have a couple of drinks, a lot of beautiful women, New York City, the new joint — you already know," Wale said excitedly.

Jigga's 40/40 closed last summer to undergo renovations and is now back with an updated look. While everyone was excited about the new club, baby Blue Ivy was a hot topic on the carpet. Ashanti couldn't be happier for the new parents, but when asked if she had caught a bit of baby fever herself, the "Foolish" singer made it clear that she isn't ready to be a mother just yet. "Oh no, boo-boo, no baby over here. I say it enough in my records," she said with a boisterous laugh.

Music mogul and record producer Irv Gotti, who has three kids of his own, told MTV News that he shared some fatherly advice with his friend Jay-Z, but he wouldn't reveal any of it. "I'll keep that between me and Hov," Irv said.

Then at that very moment, Jay breezed past the carpet trying to dodge reporters and flashing lights, but he did stop to give his old friend some love. After he and Gotti slapped each other five, Jay made a beeline for the 40/40 doors to get the party started.

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Source: http://www.mtv.com/news/articles/1677515/jay-z-40-40-club-reopening.jhtml

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Camera+ 2.4VS (for iPhone)


Camera+ has been a favorite, highly-rated iPhone photo app in the iTunes app store for a few years. The $1.99 app matches the competing Camera Genius in a lot of ways, with many features in common, though this latest version of Camera+ has a slicker interface and more photo enhancements. For its part, Camera Genius ($1.99, 3.5 stars) offers a bit more in shutter options and sharing targets. Camera+ features fall into two main categories, shooting and photo enhancing. How does it compare with the best iPhone camera apps around?

Shooting
If you use Camera+ to replace the iPhone's default Camera app, you'll get several extra shooting options. First, a timer, common to pretty much all standalone digital cameras, lets you set up a shot and walk into the photo yourself. But you don't get all of Camera Genius's ingenious ways to trigger the shutter?using a noise, on focusing, and with a full screen shutter button. These are less of a concern now that you can shoot with the iPhone's Volume button or using its front camera.

The app also, like Camera Genius, offers a "Stabilizer," which, rather than adding actual stabilization as is done optically or digitally on digital camera, simply waits till you're holding the camera steady to snap a picture. This worked equally as well as Camera Genius's equivalent. A burst mode does a better job than Camera Genius's equivalent feature. By lowering the image resolution, I could shoot more rapid photos, though of course, the resulting images couldn't be blown up as much.

Another shooting possibility that Camera+, like Camera Genius, adds to the iPhone is the ability to specify separate focus and exposure points. It takes an interesting, if less intuitive approach than Genius: You touch the screen once on the spot you want the focus, and while holding that finger down touch another spot for exposure. After this you can drag either point around anywhere on screen. This only works with the better camera on the back of the phone; with the front camera I could only set the aperture point. But this was better than Camera Genius's, which showed separate focus and exposure points for the front camera, but in fact they didn't work separately.

A final shooting tool was the ability to set the flash always on?something not available in Camera Genius, but also something that will wear down your iPhone's battery quickly.

Enhancing
After taking your shots, photos appear in a smart-looking "Lightbox"?a photo gallery that looks like a contact sheet of film photos. From here, you can touch an image to get the Edit, Share, Save, and Info buttons. The first offers Scenes, Adjust, Crop, Effects, and Borders, each with their own subchoices. "Scenes" is like the feature offered on many point-and-shoot cameras, including Clarity, Auto, Flash, BackLit, Darken, Cloudy, Shade, Fluorescent, Sunset, Night, Portrait, Beach, Scenery, Concert, Food, and Text?a healthy selection! One drawback?unlike Snapseed ($4.99, 4 stars) and Camera Genius, you can only edit photos taken in the Camera+ app itself, not existing images in the Camera roll.

But you don't get sliders to adjust the lighting the way you do in Snapseed ($4.99, 4 stars) and Camera Genius; Camera+'s Adjust tab only let you rotate and flip the image. The Cropping tool is excellent, with large easy-to-grab handles and plenty of preset aspect ratios. One problem, though, was that I couldn?t rotate a preset from portrait to landscape orientation, as I could in Camera Genius.

The FX tab is one place Camera+ shines: you get four sets of nine effects: Color, Retro, Special, and Analog. Be warned, though, that the last set is an extra-cost item, only available for preview in the base app. The Special effects include HDR, polarize, color dodge, grunge, and cross process. It's just about everything you find in Instagram (Free, 3.0 stars) and Hipstamatic ($1.99, 3.0 stars). And each effect offers an Intensity slider for further adjustment.

Sharing
Once you've got your photo all dolled up the way you want it, your choices are Flickr, Facebook, and Twitter (as well as SMS and email, which you can do in the default Photo app). Camera Genius goes a bit beyond this, with Tumblr and Picasa sharing thrown in. Of course, both are a far cry from Instagram, which encourages deep delving into its own photo-centric social network based around small, usually stylized square images.

A Lot of Plusses
Camera+ 2.4VS is a beautifully designed app that enhances your iPhone camera and photo enjoyment. I actually find its slick interface design one of the best, but Camera Genius offers more shutter and sharing options, more editing control, and lets you work with existing images. Camera+ has a better burst mode and lots of fun effects. But for the ultimate in photo correction and enhancement, look to our Editor's Choice, Snapseed for iPhone.

More iPhone App Reviews:

??? CameraBag 1.93 (for iPhone)
??? Camera+ 2.4VS (for iPhone)
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??? Lookout for iPhone
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?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/benNEabU30g/0,2817,2399064,00.asp

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Friday, January 20, 2012

Zebrafish may help speed drug discovery

Tuesday, January 17, 2012

Tiny zebrafish just may give scientists one solution to information overload in the search for new drugs therapies.

High throughput screening, which uses robotics and computers to rapidly screen drugs, genes or proteins, to identify, for example, compounds that are best at destroying cancer or restoring insulin-producing cells. The technology has both revolutionized and stymied research, said Dr. Jeffrey Mumm, biologist in the Medical College of Georgia at Georgia Health Sciences University.

While the decade-old technology can screen 100,000 compounds in a day, there is no efficient next step for whittling to a manageable number the resulting say, 2,500 compounds that on first blush appear to have potential. Consequently, drug discovery has actually stalled, creating a scientific "indigestion," Mumm said. Drug failure rates and discovery costs, on the other hand, have escalated.

"The next best thing to do is probably take all the compounds and put them into an animal model that mimics the disease you are trying to cure but nobody has that kind of budget or would know where to start with that number of candidates," Mumm said.

One solution is pairing zebrafish with reporter-based assays that make certain parts glow, according to Mumm's research published in the journal PLoS ONE. He calls it Automated Reporter Quantification.

"It's a way to cut to the chase rather than having to make educated guess about which of the 2,500 compounds are really of interest," said Mumm. Zebrafish, which start out as single cell organisms that are fully functioning by day four, already are an invaluable research model for a wide variety of diseases, such as Mumm's efforts to regenerate cells in the face of degenerative diseases of the eyes or pancreas.

To produce a model of type 1 diabetes, for example, he uses a single drug to destroy insulin-producing cells; 24 hours later, he knows those cells are gone because the glow is gone in the transparent zebrafish.

Now, he can leave the fish in the well plates, which look like plastic ice trays with cubes about the size of pencil tops and come in multiples of 96. The individual wells enable him to quickly reassess the impact of the thousands of compounds identified by high-throughput screening in a living specimen. Simply put: Does the glow come back? The next step becomes logical and doable: study the 20 or so compounds that continued to show promise in a mouse model. These steps to the fish then mouse, called biological validation, have been a real bottleneck in science post high-throughput screening, Mumm said. "This is going to give you much more thorough information about how compounds affect the overall physiology of a living being," Mumm said.

He noted that reporter-based assays number in the thousands so what they can help find is essentially limited only by the imagination.

He's used one to monitor a major signaling pathway that consistently shows up in cancer. "We hooked the pathway up to a reporter that told us whether it was on or off, then tested whether we could modulate it over time and, sure enough, it was very easy to do," Mumm said. "Name the cancer and basically you have WNT activated so there is a huge effort in cancer therapeutics to try and essentially shut it down."

###

Georgia Health Sciences University: http://www.georgiahealth.edu

Thanks to Georgia Health Sciences University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 43 time(s).

Source: http://www.labspaces.net/116748/Zebrafish_may_help_speed_drug_discovery

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Thursday, January 19, 2012

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Declines in melanoma deaths limited to the most educated

Tuesday, January 17, 2012

A new study from the American Cancer Society finds recent declines in melanoma mortality rates in non-Hispanic Whites in the U.S. mainly reflect declines in those with the highest level of education, and reveals a widening disparity in melanoma mortality rates by education. The authors say the findings call for early detection strategies to effectively target high-risk, low-educated, non-Hispanic White individuals. The study is published Online First by Archives of Dermatology.

Since the early 1990s, overall melanoma mortality rates among Non-Hispanic Whites (ages 25 to 64 years) have been declining in men and women. But it has not been known whether these death rates might differ according to socioeconomic status (SES).

To study whether melanoma death rate trends might differ according to SES, researchers led by Vilma Cokkinides, Ph. D, reviewed death certificates from 26 states, representing approximately 45 percent of the U.S. population. They found melanoma mortality declined about ten percent between over the latest ten-year span (1993-97 to 2003-07) in both men (RR= 0.916, 95% C.I.= 0.878, 0.954) and women (RR = 0.907, 95% C.I.= 0.857, 0.957).

However, declines occurred only among those with at least 13 years of education or more, irrespective of sex. In fact, there were actually non-significant increases among the least educated individuals. As a result, the educational gap in melanoma mortality rates widened by 51.7% in men and by 35.7% in women between the two time periods (1993-97 and 2003-07).

"To our knowledge, this is the first study to document this education gap in melanoma mortality trends among Non-Hispanic Whites in the U.S.," said Dr. Cokkinides. "The reasons for the widening of the educational gap in mortality rates are not yet understood, but we do know the cornerstone of melanoma control is recognizing the signs of melanoma early. Lower socioeconomic status is associated with suboptimal knowledge and awareness of melanoma, inadequate health insurance, and lower rates of skin self-examination or physician screening."

The authors conclude recent declines in melanoma mortality are largely confined to more educated groups, and that an increasingly disproportionate burden of fatal melanoma among low SES populations calls for more vigilant primary and secondary prevention education campaigns directed to high-risk, low SES individuals and the physicians that care for them.

###

American Cancer Society: http://www.cancer.org

Thanks to American Cancer Society for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 62 time(s).

Source: http://www.labspaces.net/116746/Declines_in_melanoma_deaths_limited_to_the_most_educated

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Wednesday, January 18, 2012

Man gets life sentence in Ga. girl's killing

Ryan Brunn enters Superior Court Judge Frank Mills court at the Cherokee County Justice Center in Canton, Ga. on Tuesday, Jan 17, 2012. Brunn, 20, pleaded guilty Tuesday to several charges including murder in the Dec. 2 killing of Jorelys Rivera. He responded ?Yes, sir,? when a judge asked if he was pleading guilty to the charges. The judge accepted his plea and sentenced him to life without parole. (AP Photo/Atlanta Journal & Constitution, Phil Skinner) MARIETTA DAILY OUT; GWINNETT DAILY POST OUT

Ryan Brunn enters Superior Court Judge Frank Mills court at the Cherokee County Justice Center in Canton, Ga. on Tuesday, Jan 17, 2012. Brunn, 20, pleaded guilty Tuesday to several charges including murder in the Dec. 2 killing of Jorelys Rivera. He responded ?Yes, sir,? when a judge asked if he was pleading guilty to the charges. The judge accepted his plea and sentenced him to life without parole. (AP Photo/Atlanta Journal & Constitution, Phil Skinner) MARIETTA DAILY OUT; GWINNETT DAILY POST OUT

Ryan Brunn, center, stands in front of Superior Court Judge Frank Mills at the Cherokee County Justice Center in Canton, Ga. on Tuesday, Jan 17, 2012. Brunn, 20, pleaded guilty Tuesday to several charges including murder in the Dec. 2 killing of Jorelys Rivera. He responded ?Yes, sir,? when a judge asked if he was pleading guilty to the charges. The judge accepted his plea and sentenced him to life without parole. (AP Photo/Atlanta Journal & Constitution, Phil Skinner) MARIETTA DAILY OUT; GWINNETT DAILY POST OUT

Jocelyn Rivera cries as Ryan Brunn pleas guilty in front of Superior Court Judge Frank Mills at the Cherokee County Justice Center in Canton, Ga. on Tuesday, Jan 17, 2012. Brunn, 20, pleaded guilty to several charges including murder in the Dec. 2 killing of Jorelys Rivera. He responded ?Yes, sir,? when a judge asked if he was pleading guilty to the charges. The judge accepted his plea and sentenced him to life without parole. (AP Photo/Atlanta Journal & Constitution, Phil Skinner) MARIETTA DAILY OUT; GWINNETT DAILY POST OUT

Jocelyn Rivera, left, keeps her eyes on Ryan Brunn at the Cherokee County Justice Center in Canton, Ga. on Tuesday, Jan 17, 2012. Brunn, 20, pleaded guilty to several charges including murder in the Dec. 2 killing of Jorelys Rivera. He responded ?Yes, sir,? when a judge asked if he was pleading guilty to the charges. The judge accepted his plea and sentenced him to life without parole. (AP Photo/Atlanta Journal & Constitution, Phil Skinner) MARIETTA DAILY OUT; GWINNETT DAILY POST OUT

Jocelyn Rivera cries while sitting with family members as Ryan Brunn pleas guilty in front of Superior Court Judge Frank Mills at the Cherokee County Justice Center in Canton, Ga. on Tuesday, Jan 17, 2012. Brunn, 20, pleaded guilty to several charges including murder in the Dec. 2 killing of Jorelys Rivera. He responded ?Yes, sir,? when a judge asked if he was pleading guilty to the charges. The judge accepted his plea and sentenced him to life without parole. (AP Photo/Atlanta Journal & Constitution, Phil Skinner) MARIETTA DAILY OUT; GWINNETT DAILY POST OUT

(AP) ? An apartment maintenance man in north Georgia has been sentenced to life in prison after pleading guilty to molesting and killing a 7-year-old girl, bringing an unusually swift conclusion to a case that frightened the community just over a month ago.

Speaking softly in court and with little emotion, 20-year-old Ryan Brunn quietly detailed Tuesday how he lured Jorelys Rivera (JOR'-ih-lees ruh-VEHR'-uh) into a vacant apartment, molested her, beat and stabbed her to death and stuffed her body into a trash bin.

The girl disappeared when she left the apartment complex's playground to get sodas for her friends. Brunn told the judge he used her lost roller skate to coax her into the unit in the complex where he had worked for about a month and forced her to undress.

"I didn't want her to go home and tell her mom or dad on me," Brunn said. "So I cut her."

As Brunn spoke, the Rivera's family sobbed in the front row.

"I would like to apologize for everything I've done," Brunn said, turning to the girl's family. "Lo siento," he said, which means "I'm sorry" in Spanish.

The guilty plea to murder, child molestation and other charges spared Brunn from possibly facing the death penalty ? and Rivera's family from the prospect of an emotionally devastating trial. Law enforcement officers said the speed of the case even caught them by surprise.

"It's not often that we get to see a monster appear in court and make a full admission. And certainly we don't get to see justice done this fast," said Vernon Keenan, the head of the Georgia Bureau of Investigation. He said Brunn showed in court that he was a "sociopathic killer."

"He has no remorse. And he deserves no sympathy," Keenan said. "He is a cold and calculated killer."

Page Pate, an Atlanta defense attorney who has worked on murder cases, said he was surprised by the speed of the conclusion. Brunn was indicted on the charges just a week ago. He pointed to two possible reasons that led to Brunn's decision.

"The lawyers representing him realized early on they had an uphill battle and I expect they were looking for the fastest resolution possible. Their number one objective was to save him from the death penalty," said Pate. "And the district attorney's office realized this would be a very costly trial."

Prosecutors read a statement from the girl's mother, Joselinne Rivera, who said she hopes Brunn suffers as much as her family has.

"The rest of my life I am going to feel terrible and destroyed because of the harm you did to my daughter," Joselinne Rivera said in the statement. "I desire this man the worst possible of the world, and that they do to him the worst so he suffers."

She and the family didn't comment after the hearing.

In court, Brunn said he chose Rivera after he found her skate outside her apartment building in Canton. He snapped a photo of it and then used it on Dec. 2 to persuade the girl to follow him into a vacant unit he had earlier unlocked.

"I thought to myself, I was going to lure her. I don't know why," he said, adding: "I asked her if it was hers. And she came."

When they got to the apartment, he first forced her to lie on a mattress and undress, he said. When she wanted to use the bathroom, he said he followed her in there and forced her to lie on a bathtub. He said she never asked to leave, but only if she could go home when he was finished. He said he soon grew fearful of the consequences of the assault.

"I got scared in there from what I was doing and I didn't want her to go home and tell on me," he said.

So he bound her arms with plastic ties, stuffed her mouth with a cloth dishrag and then wrapped her face in tape, Brunn said. He said he then took a razor used for slicing carpet and slit her throat. When she struggled for a few minutes, he said he hit her about five times with the skate and then wrapped her body in a blanket, which he then dumped in a trash compactor.

That night, he said, he helped search for the missing girl for about an hour, went to Wal-Mart with two friends and came home to smoke marijuana and meth. Two days later, though, he said he began "freaking out" as the search for the girl intensified.

He said he took a McDonald's receipt from his car and scrawled a note saying the girl's body was in the trash compactor, which he taped to the device. When pressed by the judge why he did that, he responded simply: "I was high."

Brunn insisted he never had sex with the girl, and prosecutors agreed to reduce charges against him from aggravated child molestation to child molestation. He also pleaded guilty to a range of other charges, including assault and abandonment of a dead body. He had no history of a criminal past and passed a background check to work at the complex.

Keenan, the GBI director, said after the hearing that investigators uncovered evidence that Brunn had molested other children. He said Brunn's speedy guilty plea gives investigators a chance to delve into Brunn's pathos to uncover what makes him tick.

"If he were on death row, we wouldn't have the opportunity to talk to him and learn and perfect our skills," he said.

Brunn, who is being transferred to state prison, said nothing else as he was escorted from courtroom but his attorney offered brief remarks.

"A child's life was lost and he was sentenced," said his attorney, David Cannon. "And that's the bottom line ladies and gentlemen. It's over."

___

Follow Bluestein at http://www.twitter.com/bluestein .

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-18-Playground%20Abduction/id-4577ba7d6b4d4915a0659f50ff3bb4f1

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Rashad Evans interview: ?Suga? focused on fight in front of him

Though former UFC light heavyweight champion Rashad Evans is focused on his fight with Phil Davis at UFC on Fox 2, there is another man who still gets on Evans' nerves: the current UFC light heavyweight champion. In fact, the mere mention of Jones' name caused the once friendly relationship between Evans and Davis to grow frosty.

"We've actually always been friendly to each other," Evans told Cagewriter. "I've always been a Phil fan. But when you're talking trash about Jon Jones, it kind of bothers me a little bit. I can't lie."

Though Evans and Jones were once friends and training partners, their relationship fell apart after Jones remarked to media that he would fight Evans. Since then, Evans has been irked by Jones.

"All the stuff that Jon has done, he deserves credit for and I respect that. He's been an amazing athlete in the sport, and he's accomplished so much. I have nothing but respect for him in that, but when he opens his mouth against me, it bothers me."

During the UFC on Fox 2 press conference, Davis mentioned what Jones said about Evans' lack of chin. Evans responded to Davis, a Penn State alumnus, by referring to the Penn State sex abuse scandal.

"Sometimes you say things and you didn't think about it when you say it. I can't tell somebody how they should feel about something. It was a lesson that I learned about being a little bit more conscious and watching what I say because you never know how it's going to affect people in different ways."

Both Evans and Davis were collegiate wrestlers, but Davis made a comment that he is the only one who truly has wrestling skills. According to Evans, there is a big difference between collegiate wrestling and MMA wrestling.

"What it comes down to is that he can be the best college wrestler in the world. He can have all the accolades. That's awesome. But we're not wrestling college wrestling. This is a fight. You can have the best college wrestling in the world, but you can have terrible MMA wrestling. His MMA wrestling is OK. It's not phenomenal. It's not exceptional. But his transitions from his punches to a takedown are trash," Evans said.

Davis was an NCAA Division I wrestling champion, but Evans doesn't see him as a well-rounded fighter.

"It's about timing and his timing is off. He's not comfortable standing up and punching, and it's a two-part thing. That's the other part of it. You can have a great shot. Great wrestling, but if you're afraid to get punched, or if you don't have good set-ups for your takedowns, then it doesn't matter. You can't execute because you're too afraid to get hit. Or you spend too much time thinking about it. The moment you think about the shot, the moment I see it. If I see it, it's too late. You're not going to shoot on me."

Next Saturday, Evans will fight in his adopted city of Chicago, just hours away from Michigan State, where he went to school. Logic would say that he would get a warm reception from the crowd, but Evans is usually booed by crowds. He doesn't expect any change from his fellow Midwesterners.

"Of course I expect to be booed. People always have to find the bad guy, and for some reason, the look on my face or something, people just want to boo me.That's fine. I know who I am as a person, and if they boo me, they boo me. That's OK. It doesn't make me lose sleep at night. I know who I am in real life. The same people that boo you are the same people who will ask you for a picture an an autograph. They don't know why they boo me."

Evans is often cast as a villain in fights, but he doesn't relish the role, like Chael Sonnen or Josh Koscheck does.

"It's so far from my character. People who know me in real life know that's on the extreme of the other end of who I am. So when people boo me, or they say things about me, 'Rashad thinks he's this, Rashad thinks he's that,' it does bother me to a certain extent, but then I've got to remember that it's not me they're saying it about. It's a character of who they think I am, and I've got to divorce myself from that character."

He also has learned to take any promises of title shots with a shaker's worth of salt. Evans has been promised title shots with Mauricio Rua and Jones, but injuries and timing have gotten in the way. Again, Evans has been promised a shot at Jones with a win over Davis, but he knows better than to put stock in it.

"No matter what, it's not about the next fight after this one. The only fight that matters is this fight. What comes after this is for the fans to anticipate and think about. For me? Nothing matters besides the fight that I have. And that's the way it should be. Whether I've been promised something or not. Only thing I care about, the only thing I think about is the fight in front of me."

Source: http://sports.yahoo.com/blogs/mma-cagewriter/rashad-evans-interview-suga-focused-fight-front-him-213006869.html

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